Barcelona, 10 October 2024 - DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently.

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

In a review published in Current Opinion in Structural Biology on May 12, researchers from the Institute of Biophysics of the Chinese Academy Sciences have reviewed the intricate molecular ...

It takes a lot of packaging to squeeze DNA into the nucleus of a cell. The DNA in our chromosomes is packaged into nucleosomes, which consist of about 150 DNA base pairs wrapped around eight-protein ...

K. Luger, A.W. Mader, R.K. Richmond, D.F. Sargent, T.J. Richmond, "Crystal structure of the nucleosome core particle at 2.8 Å resolution," Nature, 389:251-60, 1997 ...