Alzheimer’s has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain’s energy supply help drive the disease—and ...

For more than a century, Alzheimer’s disease has been treated as a one‑way slide, something that could perhaps be slowed but ...

When scientists opened the doors of a research facility and let carefully bred lab mice loose into a fenced field, they ...

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

In the wild, a mouse or rat leads a precarious life. In the city, they dodge traps, poisons, and broom-wielding humans. In the countryside, they face owls, shotguns, and more poison. As Australia’s ...

A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

In a controlled experiment, researchers took lab mice and placed them in large, enclosed fields where they could roam freely and interact with natural elements such as grass and dirt. This experience ...

For decades, preclinical testing in mice, rats, and nonhuman primates has been a crucial part of drug development, an important although not infallible way to ensure some measure of safety for human ...