Endoreduplication is a common process in plants that allows cells to increase their DNA content. In the tobacco cell cultures studied in this work it can be induced by simple hormone deprivation.

The Fbw7/hCDC4 protein is the substrate specificity component of an Skp1–Cullin-F–Box ubiquitin ligase complex. Lesions in the Fbw7 gene have been observed in a large list of cancers (Moberg et al., ...

Exit from the mitotic cell cycle and initiation of cell differentiation frequently coincides with the onset of endoreduplication, a modified cell cycle during which DNA continues to be duplicated in ...

REISMAN, Zuelzer and Mitani 1 described polyploidy and endoreduplication of chromosomes in a patient being treated for acute leukemia. They ascribed these abnormalities to a primary chromosomal ...

c-Jun N-terminal kinase (JNK) is activated by diverse cell stimuli, including stress, growth factors, and cytokines. Traditionally, activation of JNK by stress treatment is thought to induce cell ...

The function of an enzyme, critical to most forms of life, has been revealed. A research team, led by the John Innes Centre found that the enzyme DNA topoisomerase VI (topo VI) performs a critical ...